Document Type : Authored Book

Authors

• Arezou Rezaei ¹
• Mohammad Reza Khorramizadeh ²
• Zainab Asghari ¹

¹ School of Biology, Damghan University, Damghan, Iran

² Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences

Abstract

This book provides a comprehensive and detailed exploration of the mitochondrion, the essential intracellular organelle known as the powerhouse of the eukaryotic cell. It delves into the complex structure and multifaceted functions of this organelle, which are critical for understanding both normal cellular physiology and the pathophysiology of various diseases.
The book is systematically structured into seven insightful chapters:

Chapter 1: Covers the history, identification, and structure of the mitochondrion, along with vital biochemical cycles and the energy transfer chain.
Chapter 2: Examines mitochondrial function, including protein import, oxidative stress, intracellular calcium regulation, and its central role in apoptosis (programmed cell death).
Chapter 3: Explores mitochondrial dynamics, inheritance, and the organelle's fate throughout the cell cycle.
Chapter 4: Details major mitochondrial diseases (e.g., Diabetes, Alzheimer's, Parkinson's, Huntington's, Cancer) and introduces assisted reproductive techniques to prevent their inheritance.
Chapter 5: Provides an in-depth analysis of the mitochondrion's role in the aging process.
Chapter 6: Discusses the intriguing connection between lifestyle factors and mitochondrial diseases.
Chapter 7: Serves as a practical guide for researchers, outlining various methods for studying mitochondrial structure and function, such as measuring ATP/NAD+, mass spectrometry, and mtDNA tracking.

Compiled with meticulous care, this volume is a foundational resource recommended for students at all levels, as well as for researchers and professors interested in cell and molecular biology. It successfully bridges fundamental knowledge with contemporary research on mitochondria's role in health, disease, and aging.
 

Cover

Main Subjects

• Biology

ISBN: 9786229741375